Figure 1: Phosphoinositide metabolism and associated disease. Legend: A: chemical structure of phosphatidylinositol with numbered positions of the inositol ring indicated. B: depiction of the main pathways of phosphoinositide synthesis and degradation. Diseases associated with the kinases and phosphatases that regulate this interconversion are indicated. From McCrea HJ, De Camilli P. Mutations in Phosphoinositide Metabolizing Enzymes and Human Disease. Physiology 24: 8-16, 2009