Figure 2: Subcellular distribution of the seven phosphoinositides. Legend: A: each phosphoinositide is thought to have its own predominant subcellular localization, as indicated (modified from a drawing by Andrea Raimondi). B : localization of PI(4,5)P2, PI4P, and PI3P, as revealed by transfected GFP fusion of protein modules that selectively bind these phosphoinositides. The localization of the fusion protein is shown in green: plasma membrane for PI(4,5)P2, the Golgi complex for PI4P, and endosomes for PI3P. (Reprinted with permission from Ref. 24.) From McCrea HJ, De Camilli P. Mutations in Phosphoinositide Metabolizing Enzymes and Human Disease. Physiology 24: 8-16, 2009